Updates in nonhormonal therapy for peri/menopause symptoms

Research . FemTalkAsia

Summary

The article discusses recent advancements in nonhormonal therapies for managing perimenopausal and menopausal symptoms, highlighting the efficacy of neurokinin B antagonists and updated guidelines from The Menopause Society (Voedisch et al., 2025).

FemTalkAsia Takeaways

• Neurokinin B Antagonists: Emerging treatments, such as neurokinin B antagonists, have shown promise in effectively managing vasomotor symptoms associated with menopause.
• Updated Guidelines: The Menopause Society has released updated guidelines on nonhormonal therapies, providing healthcare professionals with evidence-based recommendations for managing menopausal symptoms without hormone therapy.
• Alternative Therapies: Nonhormonal options, including lifestyle modifications, acupuncture, cognitive behavioral therapy, and pharmacological agents like SSRIs/SNRIs, gabapentin, and clonidine, are explored for their efficacy and cardiovascular safety in treating vasomotor symptoms.
• Treatment Satisfaction and Unmet Needs: There is a need to address treatment satisfaction and unmet needs among menopausal women, as well as to align new treatment expectations between women and physicians.
• Practice Patterns and Perspectives: Healthcare providers are increasingly recommending complementary approaches, such as diet changes, exercise, and stress reduction techniques, to manage menopausal symptoms, reflecting a broader perspective on treatment options.