Hormone Therapy and Alzheimer’s: New Study Warns of Potential Risks

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A recent study from Mass General Brigham suggests that hormone replacement therapy (HRT) for menopause may increase the risk of Alzheimer’s disease in older women. The study, published in Science Advances, found that women in their 60s and beyond who used HRT had a higher buildup of tau proteins, which contribute to Alzheimer’s.

What the Study Found

Researchers analyzed brain scans of women aged 50 and older. They discovered that those over 70 who had taken HRT showed increased tau protein buildup, a key marker of Alzheimer’s disease. However, women who stopped HRT in their 50s or early 60s did not show the same risk.

“The key message is that the effects of hormone therapy on the brain are not the same for all women,” said Dr. Gillian Einstein, a neuroscientist at the University of Toronto who was not involved in the study.

Timing Matters

The findings suggest that starting HRT at the right time could be crucial. Women who began hormone therapy closer to menopause seemed to have fewer risks, while those who started it later were more vulnerable to Alzheimer’s-related changes.

“It really emphasizes that there’s a window of opportunity,” said Dr. Rachel Buckley, the study’s senior author. “If you start too late, the risks may outweigh the benefits.”

What This Means for Women

Doctors have long debated the benefits and risks of HRT. While it helps with menopause symptoms like hot flashes and bone loss, the potential risks for cognitive health must be considered. Experts suggest women talk to their doctors about the best time to start or stop HRT based on their individual health history.

“This study doesn’t mean all women should avoid HRT,” said Dr. Lisa Mosconi, a neuroscientist at Weill Cornell Medicine. “It means we need to personalize treatment and be mindful of when it starts and stops.”

Final Thoughts

Menopause care is not one-size-fits-all. If you’re considering HRT, it’s essential to weigh the benefits and risks with a healthcare provider. This study highlights the importance of timing in hormone therapy decisions. For more updates on women’s health and menopause research, stay tuned to our latest news section.

Full Credit: Drug commonly taken by older women linked to ‘worse Alzheimer’s outcomes’